Tretinoin belongs to the class of first-generation retinoids and is a special form of vitamin A. Depending on the form of release, this retinoid can be administered both topically and internally.
To the market of Australia, Tretinoin comes in the following dosage forms:
Of all retinoids, Tretinoin is one of the most studied. Most often, this drug is used for the treatment of mild and moderately severe acne stage in adolescents and adults.
The drug can also be used to reduce wrinkles, caused by a decrease in the synthesis of structural proteins and hyaluronic acid or slowing of the regeneration processes.
Tretinoin gels and creams are available in Australia under the trade names Retin-A, Retrieve, Stieva-A, and are intended for topical use. It is proved that the drug reduces the production of oil and inhibits the formation of micro-medones.
Excess growth of the epithelium of the ducts of the sebaceous glands stops under the influence of Tretinoin. As a consequence, the release of dead cells improves, as well as their release to the skin surface.
In addition, this retinoid has an anti-inflammatory effect and increases the resistance of cells directly in the focus of the purulent process. As Australian experts note, topical application of Tretinoin leads to a more rapid epidermis renewal and an increase in its thickness.
You can use Tretinoin cream to normalize the activity of the sebaceous glands, effectively control the pigmentation and reduce the pores. However, the use of the drug may provoke an increase in the photosensitivity of the facial skin.
Thus, if you use the drug regularly, you should avoid exposure to the sun, and, if this is not possible, you should take special precautions.
Using sunscreens and wearing clothes over damaged skin will help protect it from sunburn and stop the development of inflammatory processes.
Regardless of age, some Australians may experience severe irritation, itching and burning of the skin when using Tretinoin. As a rule, these side effects eventually pass, yet they can cause great discomfort.
To reduce the risk of these side effects, Tretinoin cream should be applied in small amounts and only on the affected areas of the face.
Tretinoin is supplied to Australian pharmacies in low, medium and high concentrations. Therapeutic dose of the drug is selected strictly individually. However, you always should begin with minimal doses, which you should gradually increase.
If you missed applying Tretinoin cream, it is unacceptable to apply a double dose the next day to replenish the one you missed. Just apply the cream as usual and try not to miss any more days.
The first effect of Tretinoin use will be visible after several months of regular use. Usually, the duration of treatment is 3 months.
To date, there are several drugs on the Australian market to deal with acne, however Tretinoin is the most effective and popular.
Along with the anti-acne treatment, this first-generation retinoid is also used to treat myeloid leukemia, and namely, one of its acute forms, promyelocytic leukemia. With the development of this disease, a certain type of blood cells degenerates into malignant cells.
White blood cells do not mature and do not turn into fully developed functional cells, and start to quickly and uncontrollably divide. They displace healthy cells and take their place in the bone marrow.
The drug is prescribed at the initial stage of intensive care. Tretinoin inhibits an amount of immature white blood cells and prevents their division.
For the treatment of malignant tumor disease of white blood cells, citizens of Australia can buy Tretinoin in local pharmacies in the form of 10mg capsules, which have a yellow/reddish brown color.
The capsules are taken twice a day, and the therapeutic dosage is selected for each individual patient, and the therapeutic dosage and duration of treatment are determined individually.
Tretinoin dose for adult patients is calculated based on the surface area of the body and averages about 8 capsules of the drug (up to 45 mg Retinoid per each square meter of the body surface).
The same dose is used for the treatment of adolescents and children. Yet in poor tolerability and the manifestation of side effects, it is recommended to reduce the daily dose.
Patients with diseased kidney and liver may need a dose adjustment for Tretinoin. Subject to remission of the disease, the total duration of therapy is one to three months.
The use of Tretinoin capsules can promote such side effects, as headaches, baldness, skin inflammation, decreased appetite, arrhythmia, and vomiting.
This retinoid can cause congenital anomalies or irreversible damage to the fetus, so it is not recommended to use it during pregnancy.
Since Tretinoin is excreted from the body by the kidneys, people of Australia with inflammatory diseases of the kidneys should be careful, if they use this drug.