Spironolactone-based drugs are used to normalize blood pressure. Every patient in Australia, who wants to take an effective antihypertensive drug, can buy Spironolactone.
Spironolactone is a potassium-sparing diuretic, whose antihypertensive effect is due to aldosterone blockade. The hormone of the adrenal cortex increases the excretion of potassium ions from the body.
Being an antagonist of aldosterone, Spironolactone:
Enhancement of diuresis after the intake of Spironolactone helps normalize blood pressure.
After the ingestion, Spironolactone is rapidly absorbed and has almost 100% bioavailability. The intake of fatty and high-calorie foods increases the degree of the drug absorption. Maximum plasma concentrations are achieved 2-4 hours after the oral administration.
Excretion of Spironolactone from the body is carried out in two phases. The primary half-life is 12 hours. The second phase of elimination occurs within 12-96 hours.
You can buy Spironolactone in conventional pharmacies of Australia. Tablets can contain 25 mg or 100 mg of active ingredient. To avoid a medical examination and the need to get a prescription from a medical specialist, patients can buy Spironolactone online without a prescription.
To normalize blood pressure, take 50-100 mg of Spironolactone daily. The daily dose of this diuretic can be gradually increased to 200 mg once every two weeks. You should expect the first signs of improvement no earlier than 2 weeks of Spironolactone use.
The daily dose of Spironolactone for reducing the severity of congestive heart failure symptoms can vary from 25 to 200-mg once or twice a day. The maintenance dose of the diuretic is selected individually for each patient.
Most endocrinologists and nephrologists in Australia use Spironolactone to diagnose hyperaldosteronism. In a short diagnostic test, doctors prescribe 400 mg of Spironolactone for 4 days. If the level of potassium in the blood increases with the use of a diuretic, and decreases after the drug is discontinued, it can be assumed that the patient has primary hyperaldosteronism.
For a long-term diagnostic test, 400 mg of Spironolactone should be taken every day for 20-30 days. Normalization of blood pressure and potassium blood level can be considered the basis for diagnosing the primary hyperaldosteronism.
Once the patient is diagnosed with “primary hyperaldosteronism”, his daily dose of Spironolactone can be 100mg – 400 mg, divided into 1-4 doses. Since surgical intervention is the main treatment for hyperaldosteronism, Spironolactone should be taken during the entire period of preparation for surgery.
Strict control of the potassium level is required during the use of Spironolactone to avoid the risk of hyperkalemia. The potassium level and the kidney function should be examined in 3 days and in 1 week after the start of the diuretic use, then every month for 3 months.
Spironolactone is the only potassium-sparing diuretic in Australia, the use of which blocks the synthesis of aldosterone and prevents the associated undesirable consequences, like hypertrophy of cardiomyocytes, stimulation of free radical production and others.
Spironolactone improves endothelial regulation of vascular tone. The use of the diuretic during a year results in a significant improvement in blood pressure levels.
Advantages of Spironolactone:
Spironolactone was developed in 1957. January 21, 1960 the first diuretic for the normalization of blood pressure was approved in the USA under the trademark Aldactone.
The anti-androgenic activity of Spironolactone was proved in 1969. This served as the basis for the possible use of the drug in the treatment of acne, as well as against baldness. However, the poor solubility of the drug limits the creation of effective and aesthetically acceptable formulations for topical acne treatment.
The development of Spironolactone-based creams, gels and ointments is further complicated by the fact that the antiandrogenic activity of the drug appears only in very high dosages. However, Spironolactone Cream is currently being studied to assess its effectiveness for topical acne treatment.
The first drugs, based on Spironolactone, have been used in Australia since the early 1960s. At present, topical Spironolactone trademarks in Australia are Spiractin, Aldactone and Aldazide. Australian suppliers of diuretics are such pharmaceutical companies, as Proqualix, Pfizer and Alphapharm.
If a patient can not afford to buy Spironolactone because of its high cost, he can always find the drug on the online pharmacies of Australia at a reduced price.