Mirtazapine is used to treat serious mental illnesses, like the major depressive disorder (MDD). Patients with a history of mental disorders, who want to take medicine to prevent relapse of the disease, can buy Mirtazapine in Australia.

• Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSAs) with a tetracyclic structure with a broad profile of pharmacological activity. The action mechanism of
• Mirtazapine is aimed at strengthening the central noradrenergic and serotonergic transmission of the nerve impulses.

In addition to affecting the receptors of serotonin and norepinephrine, Mirtazapine is also a histamine receptor antagonist. This increases the efficacy of the antidepressant in the treatment of depression with sleep disorders and allows avoiding the need for using additional sleeping pills.

Mirtazapine is effective in the treatment of psychological diseases, which are accompanied by such disorders, as:

• sleep disorders
• frequent change of mood
• psychomotor inhibition
• inability to experience pleasure and joy

After oral administration, Mirtazapine is absorbed rapidly, and its bioavailability is about 50%. The maximum concentrations are achieved 120 minutes after the oral administration. The average half-life is about 20-40 hours. Stable Mirtazapine concentrations in blood plasma are achieved in 3-4 days of regular intake of the antidepressant.

To buy Mirtazapine in Australian pharmacies, patients need to choose one of the following dosage forms:

• tablets of 15 mg, 30 mg and 45 mg
• orally dispersible tablets (ODT) of 15 mg, 30 mg and 45 mg

Mirtazapine is an economically beneficial therapeutic strategy for the treatment of mental illnesses. Treatment of the MDD with NaSSA is more effective, than the use of Amitriptyline and Fluoxetine. High consumer price of Mirtazapine in Australia is compensated by lesser side effects and less need for medical care.

Mirtazapine tablets should be taken once a day, regardless of meals. Preferred time of administration – before bedtime. Yet you can divide a high daily dose of Mirtazapine in 2 intakes – in the morning and in the evening.

Unlike the conventional tablets, ODTs are more fragile, so they should not be squeezed through the foil of the blister pack, as they may break. You should open the package by gently pulling the marked edge of the blister foil. Once you took it out, you must immediately place the ODT on your tongue.

The initial daily dose of Mirtazapine for the treatment of mental disorders in adults is 15 mg. To obtain an optimal clinical response, the daily dose of Mirtazapine can be increased to 30 mg, 45 mg or 60 mg. No dose adjustment is required for the use of the antidepressant in elderly patients, older than 65 years.

The first signs of improvement are observed after 7-14 days of regular Mirtazapine use. You should discontinue Mirtazapine, if you don’t get a pronounced reduction in the symptoms of depressive disorders within 14-30 days.

Advantages of the MDD treatment with Mirtazapine:

• effective combination of antidepressant and antipanic properties;
• significantly better safety profile and lower toxicity, compared to tricyclic antidepressants (TCAs);
• significantly faster development of the effect, compared to other antidepressants, for example, from the SSRI group.

Several articles on Mirtazapine were published in the independent peer-reviewed journal Australian Prescriber. Comments of medical specialists give grounds to believe that Mirtazapine is one of the most promising antidepressants for use in the psychiatrists’ practice.

Most researchers agree that Mirtazapine is superior in efficacy to other mixed-action antidepressants. For example, drugs from the group of serotonin reuptake inhibitors and norepinephrine (SNRIs) increase the level of neurotransmitters only at the maximum therapeutic doses. Mirtazapine, thanks to its unique action, promotes the reuptake of serotonin and norepinephrine within the therapeutic doses.

To learn more about Mirtazapine advantages in the treatment of mental disorders, patients can visit the official website of the Monthly Index of Medical Specialties (MIMS), which publishes only the most current information about medications.

Mirtazapine is the first antidepressant from the NaSSAs group. It was synthesized in 1989 by the company Organon International. Five years later, Mirtazapine was approved for the treatment of MDD in the Netherlands.

In Australia, Mirtazapine obtained a marketing authorization on July 10, 2002. Mirtazapine brands are: Remeron, Axit, Mirtazon, Avanza, Milivin and Aurozapine. In addition, the antidepressant is also sold under its non-proprietary name.