Domperidone is a medication used to relieve symptoms of idiopathic or diabetic gastroparesis. Patients who want to take a reliable antiemetic can buy Domperidone in Australia.

Domperidone is a dopamine antagonist of prokinetic group. By suppressing activity of peripheral dopamine receptors, Domperidone eliminates inhibitory effect of dopamine on gastric motility. By suppressing dopamine effect, Domperidone increases spontaneous activity of the stomach.

Effectiveness of Domperidone in improvement of gastric motility is caused by the following mechanisms of action:

• decrease in transit time of food through the small intestine;
• activation of peristalsis of the esophagus and antrum of the stomach;
• increase in tone of the lower esophageal sphincter that contributes to antiemetic effect;
• increase in frequency, amplitude and duration of the duodenum contractions.

After oral use, Domperidone is well and quickly absorbed. The drug has a low bioavailability, caused by intense primary metabolism in the intestinal wall and liver. Consumption of fatty and high-calorie foods, as well as decreased acidity of the stomach slow down and reduce absorption of the drug.

The maximum concentration of Domperidone in the blood plasma is reached 0.5-1 hour after oral administration. If the medicine is taken after meal, it will take more time to reach the maximum concentration than when taking on an empty stomach. Half-life of Domperidone makes about 7-9 hours.

One can buy Domperidone in Australia under the brand name Motilium, as well as under the non-proprietary name. Each Domperidone tablet contains 10 mg of the active substance. Such large pharmacy chains as Terry White Chemists, Medreich, GENRX and others are engaged in sales of this drug.

If price of Domperidone seems too high at regular pharmacy, a patient can buy this medicine online at a reduced price. In addition, one can buy Domperidone without a prescription on online pharmacies of Australia.

Adults and children over 12 years of age can take Domperidone. The usual dose is one tablet with each main meal. The optimal time of intake is 15-30 minutes before meal. To eliminate acute attacks of nausea and vomiting, 7 days of regular use of Domperidone can be required.

To mitigate symptoms of idiopathic or diabetic gastroparesis, the initial duration of Domperidone use makes one month. Every 4 weeks, the attending physician should evaluate appropriateness of further use of this medication. The maximum duration of Domperidone use makes 6 months.

Advantages of using Domperidone:

• eliminates dyspepsia symptoms;
• improves diabetes symptoms and decreases the need for insulin in patients with diabetic gastroparesis;
• does not overcome the blood brain barrier, resulting in absence of central side effects.

Pregnant women often suffer from toxicosis, so they need adequate antiemetic therapy during pregnancy. However, safety of using Domperidone during pregnancy has not received enough clinical evidence.

Despite the fact that Domperidone has a high safety profile, Australia’s medical experts do not advise to use this medicine during breastfeeding. When using Domperidone during breastfeeding, risk of cardiovascular side effects increases in infants.

Domperidone was developed in 1974 by a pharmaceutical company Janssen Pharmaceutica, which is a subsidiary of Johnson & Johnson. Initially, use of a new drug was suggested as an antipsychotic. However, during studies, a significant antiemetic effect of Domperidone was discovered and it has become available as a drug to stop nausea and vomiting.

In Australia, Domperidone has been used to eliminate nausea and vomiting since May 13, 1992, when the drug under the brand name Motilium received a marketing authorization.

To date, Domperidone is available for sale both at usual drugstores of Australia and on online pharmacies. If a patient doubts regarding quality or effectiveness of this drug before purchase, he can visit the official website of the Monthly Index of Medical Specialties (MIMS). Only the most current information on medicines, including Domperidone is published on the official website of the MIMS.